Synthesis of acylamino acid esters of nucleoside 5'-phosphates and their investigation with PMR and CD spectra

核苷5'-磷酸酯酰氨基酸酯的合成及其PMR和CD光谱研究

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Abstract

The acylamino acid esters of nucleoside 5'-phosphates are synthesized via condensation of N-(N'-acylaminoacyl) imidazoles with nucleoside 5'-phosphates. The PMR and CD spectra of the esters obtained are studied. The 3'-isomers of the substances under study are observed to have a shift in the conformational N in equilibrium S equilibrium of the carbohydrate moiety in favour of the S-form as compared to the initial nucleosides and their 2'-acyl esters.

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