The immunomodulatory potential of the arylmethylaminosteroid sc1o
芳基甲基氨基类固醇 sc1o 的免疫调节潜力
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作者：Leonard Blum, Thomas Ulshöfer, Marina Henke, Reimar Krieg, Isabell Berneburg, Gerd Geisslinger, Katja Becker, Michael J Parnham, Susanne Schiffmann
Key messages
• The anti-parasitic steroid compound 1o (sc1o) can modulate human immune cells. • Sc1o amplified the potential of M1 macrophages. • Sc1o shifts M2 macrophages to a M1 phenotype. • Dendritic cell differentiation and activation was ambiguously modulated. • Administration of sc1o could possibly assist the anti-parasitic defence.
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