Abstract
Significant literature evidence of retinal detachment prophylaxis safety and effectiveness for asymptomatic but high-risk eyes has appeared during the last five years. But it is still deemed "insufficient evidence to guide management" of asymptomatic fellow eyes in the American Academy of Ophthalmology's Preferred Practice Pattern for 2025. However, both focal and encircling prophylaxis for asymptomatic fellow eyes with lattice degeneration, and encircling laser prophylaxis for asymptomatic fellow eyes with attached posterior vitreous, now justify treatment consideration versus continued observation, based on the evidence we do have, even though it is not "level one".