Aims
Diabetic retinopathy (DR) is the most common complication of diabetes. The inflammatory milieu of diabetes
Background and aims
Diabetic retinopathy (DR) is the most common complication of diabetes. The inflammatory milieu of diabetes
Conclusions
miR-17-92 methylation in PBMCs could help understand DR's pathogenesis and identify individuals at the risk of severe DR for early intervention.
Methods
PBMCs were separated from the whole blood of DR individuals using density gradient centrifugation. DNA was isolated, and methylation of micro-RNA (miR)-17-92 cluster was evaluated.
Results
We observed that the miR-17-92 cluster was hypermethylated in DR individuals; specifically, this change was most remarkable with proliferative-DR (PDR). Conclusions: miR-17-92 methylation in PBMCs could help understand DR's pathogenesis and identify individuals at the risk of severe DR for early intervention.