Abstract
Small lymphocytic lymphoma is generally considered one of the indolent non-Hodgkin lymphoma with slow progression. However, in certain cases of small lymphocytic lymphoma (SLL), an atypical clinical presentation may be observed, such as musculocutaneous involvement, which needs to be differentiated from uncontrollable cellulitis or dermatitis. Compared with T-cell leukemia/lymphoma, cutaneous lesions in patients with SLL are far less common. The current study presented a rare case of SLL with an unusual clinical manifestation, rapid disease progression and therapeutic response after a systemic therapy regimen was applied.