Abstract
Malignant melanoma is a type of skin cancer with high morbidity and mortality. Therapeutic strategies should be individualized in order to increase the survival rate. The aim of this study was to assess the effect of lidocaine on skin healing and immune function after operation of patients with melanoma. Sixty patients with melanoma were selected from those treated in Bishan Hospital between August 2014 and August 2016. The patients were randomly divided into lidocaine group and control group. Lidocaine group was locally treated with an intradermic injection of 2% lidocaine solution in dose of 1.5 mg/kg and the control group received the same quantity of saline solution. In the lidocaine group, the rates of skin temperature, drug reaction, healing and infection were higher than the corresponding rates in the C group. The local application of lidocaine can promote wound healing to a certain extent, reduce pain, and promote postoperative skin reconstruction.