Abstract
The effects of propofol vs. sevoflurane combined with remifentanil on the pain index, inflammatory factors and postoperative cognitive function in spine fracture patients were studied and analyzed. A total of 62 patients with vertebral fracture were randomly divided into the propofol group (P group, n=41) and the sevoflurane group (S group, n=41). P group used induction anesthesia with propofol, and maintained anesthesia via intravenous injection of remifentanil. While patients in S group received induction anesthesia with sevoflurane, and also remifentanil as the maintained anesthesia. Results showed that extubation time, eye-opening time and response time of P group were lower than S group (p<0.05). The VAS score 48 h after surgery in P group was significantly lower than the S group (p<0.05). Levels of IL-6, IL-1β, ICAM-1 and MMP-9 in serum in P group were lower than those in S group (p<0.05). Mini-mental state examination (MMSE) score 24 h after surgery in P group was higher than that in S group (p<0.01). Compared with sevoflurane anesthesia, propofol combined with remifentanil anesthesia on spine fracture patients can significantly decrease the pain index and inflammatory reaction, shorten the postoperative recovery time.