Abstract
BACKGROUND: To date, few studies have evaluated the role of peripheral blood T lymphocyte subsets in patients with clear cell renal cell carcinoma (ccRCC). Here we measured the levels of peripheral blood T lymphocyte subsets and evaluated its prognostic value in ccRCC. METHODS: Data from 122 patients with RCC from January 2018 to January 2020 were collected. Preoperative peripheral blood T lymphocyte subsets and medical records were analyzed. Kaplan-Meier cures and log rank test were used for analyzing overall survival (OS). Univariate and multivariate survival analyses were underwent by performing the Cox proportional hazards models. Correlations were tested by Pearson's correlation analysis. RESULTS: Of 122 patients, a total of 80 ccRCC patients was enrolled. Patients with low CD3(+) T cells and low CD4(+)/CD8(+) ratio displayed a worse OS than patients with high CD3(+) T cells and high CD4(+)/CD8(+) ratio (P=0.029 and 0.002, respectively). Multivariate analyses showed CD3(+) T cells and CD4(+)/CD8(+) ratio were independent predictive factors for the OS (HR: 0.295, 95% CI, 0.091-0.956; P=0.042 and HR: 0.244, 95% CI, 0.065-0.920; P=0.037, respectively). Moreover, NLR negatively correlated with both levels of CD3(+) T cells and CD4(+)/CD8(+) ratio (P<0.001, r=-0.398 and P=0.012, r=-0.280, respectively). CONCLUSIONS: The findings of our study suggest that preoperative CD3(+) T cells and CD4(+)/CD8(+) ratio in peripheral blood are independent predictors for patients with ccRCC.