A single-molecule view of telomerase regulation at telomeres

从单分子视角观察端粒酶在端粒处的调控

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Abstract

Telomerase plays a key role in the immortalization of cancer cells by maintaining telomeres length. Using single-molecule imaging of telomerase RNA molecules in cancer cells, we recently reported novel insights into the role of Cajal bodies in telomerase biogenesis and the regulation of telomerase recruitment to telomeres.

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