Abstract
We recently developed a Brca1 coiled-coil mutant mouse model (Brca1(CC) ). Brca1(CC/CC) results in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia. Brca1(CC/CC) cells lacked Rad51 foci and were PARP inhibitor sensitive. Strikingly, inter-crossing with Brca1(Δ11) generated Brca1 (CC/Δ11) mice that were developmentally normal.