PD-L1 checkpoint inhibition and anti-CTLA-4 whole tumor cell vaccination counter adaptive immune resistance: A mouse neuroblastoma model that mimics human disease
PD-L1 检查点抑制和抗 CTLA-4 全肿瘤细胞疫苗接种对抗适应性免疫抵抗：模拟人类疾病的小鼠神经母细胞瘤模型
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作者：Priya Srinivasan, Xiaofang Wu, Mousumi Basu, Christopher Rossi, Anthony D Sandler
| 期刊： | PLoS Medicine | 影响因子： | 10.500 |
| 时间： | 2018 | 起止号： | 2018 Jan 29;15(1):e1002497. |
| doi： | 10.1371/journal.pmed.1002497 | 种属： | Mouse |
| 研究方向： | 信号转导、神经、肿瘤 | 细胞类型： | 肿瘤细胞 |
| 信号通路： | Checkpoint | |
Background
Adaptive immune resistance induces an immunosuppressive tumor environment that enables immune evasion. This phenomenon
Conclusions
This study demonstrates the role PD-L1 plays in neuroblastoma's resistance to immunity and defines the nonredundant effect of combination checkpoint inhibition with vaccine therapy in a mouse model. High-risk, nonimmunogenic human tumors display both diminished PD-L1 expression and adaptive immune resistance. Paradoxically, high-risk tumors may be more responsive to effective vaccine therapy because of their apparent lack of adaptive immune resistance.
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