Hippocalcin-like 1 suppresses hepatocellular carcinoma progression by promoting p21(Waf/Cip1) stabilization by activating the ERK1/2-MAPK pathway

Hippocalcin-like 1 通过激活 ERK1/2-MAPK 通路促进 p21(Waf/Cip1)稳定,抑制肝细胞癌进展

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作者:Yonglong Zhang, Yanfeng Liu, Jinlin Duan, Haibo Yan, Jun Zhang, Huilu Zhang, Qi Fan, Feifei Luo, Guoquan Yan, Ke Qiao, Jie Liu

Conclusion

These findings highlight a novel tumor suppressor upstream of p21(Waf/Cip1) in attenuating cell cycle progression and provide a promising diagnostic and prognostic factor, as well as a potential therapeutic target for HCC.

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