The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer

健康个体和胰腺癌、结直肠癌、肺癌或卵巢癌患者体内游离 DNA 水平升高的来源

阅读：6

作者：Austin K Mattox, Christopher Douville, Yuxuan Wang, Maria Popoli, Janine Ptak, Natalie Silliman, Lisa Dobbyn, Joy Schaefer, Steve Lu, Alexander H Pearlman, Joshua D Cohen, Jeanne Tie, Peter Gibbs, Kamel Lahouel, Chetan Bettegowda, Ralph H Hruban, Cristian Tomasetti, Peiyong Jiang, K C Allen Chan, Yu

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2023

起止号：

2023 Oct 5;13(10):2166-2179.

doi：

10.1158/2159-8290.CD-21-1252

研究方向：

代谢、肿瘤

疾病类型：

卵巢癌、肺癌、胰腺癌

Significance

The origin of excess cfDNA in patients with cancer is unknown. Using cfDNA methylation patterns, we determined that neither the tumor nor the surrounding normal tissue contributes this excess cfDNA-rather it comes from leukocytes. This finding suggests that cancers have a systemic impact on cell turnover or DNA clearance. See related commentary by Thierry and Pisareva, p. 2122. This article is featured in Selected Articles from This Issue, p. 2109.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用；引用内容仅为补充信息，不代表本站立场。

2、若认为本页面引用内容涉及侵权，请及时与本站联系，我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容，需注明“来源：[生知库]”并获得授权；使用引用内容的，需自行联系原作者获得许可。

4、投稿及合作请联系：info@biocloudy.com。