Abstract
The classic concepts of sensitivity and specificity are commonly taught by definition only, often with discipline-specific jargon and without any tangible relation to their use in the real world. Yet, the COVID pandemic and the spotlight on diagnostic screening tests have brought a need for science and health care students, health professionals, and the general public to have improved understanding of sensitivity and specificity and how they connect to further interpretive values. These understandings are critical for correct communications and explanations to those outside the sciences. Using simple candies or marbles as visuals, in conjunction with real-world scenarios, this activity was designed to help frame these concepts for students. Additionally, this activity provides practice with basic calculations and interpretations to reinforce how data can be used in determining testing values, surrogate testing, data cutoffs, and accuracy predictions. The activity is flexible and can easily be done in 1 to 2 h in a classroom setting, as a laboratory exercise, or as an outreach or online activity.