Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling
酪氨酸激酶Fyn通过激活Drp1信号促进大鼠脑出血后细胞凋亡
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作者：Li Zhang, Lu Wang, Han Xiao, Hui Gan, Hui Chen, Shuyue Zheng, Dan Jian, Xuan Zhai, Ning Jiang, Zhao Jing, Ping Liang
Key messages
ICH induced an increase in Fyn expression in human and rat cerebral tissues. Knockdown of Fyn prevented cerebral damage following ICH. Inhibition of Fyn had no significant effects on inflammatory responses. However, the downregulation of Fyn exerted neuroprotective effects on apoptosis. Fyn perturbed ICH-induced cell apoptosis by interacting with and phosphorylating (Ser616) Drp1 in a rat ICH model.
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