Abstract
BACKGROUND: Severe cutaneous adverse reactions (SCARs) are associated with morbidity and mortality. OBJECTIVE: The aim was to determine the different types of SCARs, their morphology, common offending drugs, interventions, and outcomes. METHODS: A retrospective cohort study was conducted of all patients admitted to the dermatology service at the University Hospital of the West Indies with Stevens-Johnson syndrome (SJS), SJS/toxic epidermal necrolysis overlap (TEN), TEN, drug reaction with eosinophilia and systemic symptoms and acute generalized exanthematous pustulosis between January 1, 2012 to June 1, 2022. RESULTS: Fifty-one cases (51) met the inclusion criteria for SCAR. SJS, SJS/TEN overlap and TEN together accounted for 71.2% of cases. SCARs were most frequent in the fourth, fifth and 6th decades of life and there was a female preponderance. Antibiotics (31%) and anticonvulsants (29%) were the most common causative agents for SCARs. Most patients had at least 1 complication. The liver was the most common extracutaneous organ affected. Mortality was 7.8%. The main cause of death was sepsis. LIMITATIONS: Results were not generalizable. There were missing data and loss to follow-up. CONCLUSION: Judicious use of antimicrobials and corticosteroids may be beneficial in treatment of severe cutaneous drug reactions.