Abstract
Background: Air pollution is a well-established risk factor for cardiovascular and metabolic diseases. Although Southern Switzerland is considered a relatively low-pollution area, levels of nitrogen dioxide (NO(2)) and particulate matter (PM(10)) still exceed the latest WHO air quality guidelines. This study aimed to assess the association between long-term exposure to air pollutants, vascular aging, and body composition in a Swiss population sample. Methods: A cross-sectional analysis was conducted on 1202 participants from the Ticino Epidemiological Stiffness Study (2017-2018). Vascular health was assessed via pulse wave velocity (PWV), used to estimate vascular age. Body composition was evaluated through bioimpedance analysis, yielding fat mass index (FMI), body cellular mass (BCM), and body cellular mass index (BCMI). Individual exposure to NO(2) and PM(10) was estimated, using geocoded residential data and environmental monitoring records from 2002 to 2017. Statistical models were adjusted for major cardiovascular risk factors. Results: Higher exposure to NO(2) was significantly associated with increased vascular age (mean delta age: +0.53 years in the high exposure group) and adverse body composition markers, including higher FMI and lower BCM/BCMI. These associations remained significant after adjusting for confounders. PM(10) showed weaker associations, significant only in unadjusted models. Conclusions: Even in a relatively clean environment, exposure to NO(2) is linked to early vascular aging and unfavorable body composition. These findings reinforce the need for stricter air quality standards and underline the importance of continuous environmental health surveillance, even in regions considered low risk.