Abstract
BACKGROUND: Typhoid or enteric fever is caused by Salmonella typhi. It is largely a disease of developing nations due to poor standard of hygiene and unavailability of potable water. The most prominent feature of the infection is fever which gradually rises to a high plateau. The prevalence of typhoid fever has been on the increase which is associated with several hematological parameters. OBJECTIVES: This study was carried out to determine the changes in various hematological parameters in our study subjects. METHOD: Four Hundred- (400) samples were obtained from volunteer subjects visiting the outpatient department of the Landmark University Medical Center. 200 typhoid positive samples were collected from subjects while 200 typhoid negative blood samples served as controls (From both male and female subjects each). Widal test was carried out as a confirmatory test for typhoid fever and evaluation of the hematological parameters were performed. The hematological parameters considered includes Packed Cell Volume (PCV), White Blood Cell count (WBC), Platelet count (PLT), Lymphocyte (LYMP) their implications on both male and female typhoid fever patients were also determined. RESULTS: The result showed a significant reduction in the values for PCV, WBC, ESR and HAE concentration in typhoid positive males in comparison to typhoid negative males. In females, a significant decrease was observed in values for PCV, ESR, HAE concentration and PLT in typhoid positive females when compared to typhoid negative females. These parameters when compared showed a significant decrease recorded in PCV, ESR and HAE concentration of the typhoid positive male patients in comparison to typhoid positive female patients. CONCLUSION: This study implies that anemia, bone marrow suppression and hemaphagocytosis are likely resulting factors of typhoid fever due to the changes in the hematological parameters. Therefore, these parameters have to be further studied to allow for efficient management of this illness.