Abstract
Chirality is a prevalent characteristic of natural systems that plays a significant role in the biological activities of living organisms, and the enantiomers typically exhibit different pharmacological activities. Consequently, developing methods with high selectivity and sensitivity for chiral analysis is of great importance for pharmaceutical engineering, biomedicine, and food safety. Electrochemical chiral recognition has garnered significant attention owing to its unique advantages, including simplicity of operation, rapid response, and cost-effectiveness. The biomaterials, such as amino acids, proteins, nucleic acids, and polysaccharides, possess inherent chiral sites, excellent biocompatibility, and abundant modifiable groups, rendering them ideal candidates for constructing electrochemical chiral sensors. This review focuses on the research progress of electrochemical chiral recognition based on different biomaterials from 2019 to 2024. In addition, the distinct chiral recognition mechanisms and electrochemical analysis methods, as well as the research challenges and prospects of electrochemical chiral sensors based on biomaterials in enantiomer recognition are discussed. This review can provide a reference for further study in related fields.