Enantiotopic-group-selective coupling for unified access to carbazole atropisomers as versatile chiral chromophores

对映体选择性偶联用于统一合成咔唑阻转异构体作为多功能手性发色团

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Abstract

Chiral organic chromophores are foundational for advanced optical and electronic devices. Despite the widespread use of N-aryl carbazoles in visible-luminescent materials, chiroptical applications of their atropisomers have remained underdeveloped due to the synthetic challenge of achieving remote atroposelectivity necessitated by extended π-systems. Here, we present a unified strategy for the efficient synthesis of enantioenriched N-C and N-N carbazole atropisomers. By integrating (13)C NMR-based ligand parameterization, we achieve enantiotopic-group-selective coupling reactions that simultaneously incorporate tailored π-functionalities and establish axial chirality (up to >99:1 er) using synthetic pathways established in carbazole chemistry. Through covalent modulation and noncovalent complexation, we investigate novel chiroptical functions of carbazole atropisomers, including circular dichroism (CD), circularly polarized luminescence (CPL), charge-transfer CPL (CT-CPL), and circularly polarized thermally activated delayed fluorescence (CP-TADF). By establishing an electrostatic steering strategy for remote atroposelectivity, our work paves the way for integrating multifunctional carbazoles into advanced optical and optoelectronic technologies.

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