Stereoselective Copper-Catalyzed Cross-Coupling of α-CF(3)-Allylboronic Acids with Diazoketones

α-CF(3)-烯丙基硼酸与重氮酮的立体选择性铜催化交叉偶联反应

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Abstract

We have studied copper-catalyzed cross-coupling of chiral α-CF(3)-substituted allylboronic acids with α-diazoketones. The reaction proceeds with excellent regioselectivity and stereoselectivity via allylic rearrangement. The method is useful for formation a new allylic C(sp(3))-C(sp(3)) bond with high selectivity. The poor yield is a limitation of this reaction.

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