Background
Drug resistance is one of the major problems encountered in clinical therapy of multiple myeloma treatment. Combination treatment with several drugs may increase the sensitivity and overcome drug resistance.
Conclusions
Our results showed a new strategy to overcome drug resistance by combination of traditional chemotherapy with cold atmospheric plasma.
Methods
Here, we combined chemotherapy with a newly developed technology, cold atmospheric plasma, to enhance drug sensitivity.
Results
We found that plasma treatment had a synergistic anti-cancer effect with a first line drug (bortezomib). Based on our previous study, we further found that plasma treatment could inhibit Notch pathway and down-regulate cyp1a1 expression and enzyme activity, which contributing to the enhanced drug sensitivity to bortezomib after combination of bortezomib with gas plasma. Conclusions: Our results showed a new strategy to overcome drug resistance by combination of traditional chemotherapy with cold atmospheric plasma.