Abstract
Regional science has, in its great history since the 1950s, made a decisive contribution to a better scientific understanding of spatial development issues and dynamics and to a more effective implementation of knowledge-based regional policy in many countries of the world, in both developed and developing nations on our planet. This special issue of the annals of regional science, titled "Spotlight on the Region", celebrates the scholarly importance and impact of the late Roger Stough on regional science. The issue is comprised of fourteen self-standing on regional and urban development and highlights the critical importance of regional and urban dimensions in sustainable development. They confirm once more the seminal significance of the contributions of one of the great giants in regional science, Roger Stough.