Abstract
The One Health paradigm recognises the interconnectedness of human, animal, and environmental health, calling for collaborative and cross-sectoral responses to increasingly complex health threats. However, operationalising this vision requires more than biomedical or ecological knowledge. It requires systems thinking, structured decision-making, performance evaluation, and governance mechanisms. Management science-including decision analysis, operations research, systems modelling, and digital innovation-can play a pivotal role in transforming the One Health framework from aspirational policy to effective practice. We build upon recent interdisciplinary literature to demonstrate how Management Science is inherently transversal to One Health research fields. Drawing from examples involving artificial intelligence, data governance, and collaborative networks, we propose a revised roadmap for embedding Management Science capacity across One Health platforms, underlining the need for a human-centred, ethically grounded, and digitally enabled ecosystem for action.