Abstract
Duodenal leiomyomas are uncommon benign smooth muscle tumors that may remain clinically silent but can occasionally manifest with significant gastrointestinal bleeding, creating diagnostic difficulty because of their submucosal location. We report the case of a 72-year-old man who presented with acute gastrointestinal hemorrhage characterized by melena. Esophagogastroduodenoscopy revealed a bleeding submucosal lesion in the duodenum, and endoscopic biopsy was subsequently performed. Histopathological examination confirmed the diagnosis of duodenal leiomyoma. This case underscores the importance of considering duodenal leiomyoma in the differential diagnosis of acute gastrointestinal bleeding and highlights the diagnostic value of endoscopic biopsy in establishing a definitive histological diagnosis.