Bilateral testicular atrophy and hypogonadism induced by paratesticular leiomyosarcoma and untreated cryptorchidism

由睾丸旁平滑肌肉瘤和未经治疗的隐睾症引起的双侧睾丸萎缩和性腺功能减退

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Abstract

Paratesticular leiomyosarcomas are rare low-grade malignancies from smooth muscle, presenting as painless scrotal masses in middle-aged men. This case describes a 48-year-old with a left-sided tumor and contralateral cryptorchidism, leading to bilateral testicular compromise and hypogonadism. He presented with asymptomatic left scrotal enlargement; examination revealed a 7-cm left mass and atrophic right inguinal testis. Labs showed normal tumor markers but primary hypogonadism. Imaging confirmed no metastasis. Bilateral orchiectomy yielded grade 1 pT1 leiomyosarcoma (positive for smooth muscle actin, desmin, vimentin) on the left and atrophy on the right. At 2-year follow-up, he remains disease-free on testosterone replacement.

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