Abstract
Inguinal sebaceous gland carcinoma is extremely rare, often mistaken for inflammatory skin lesions, leading to delays in diagnosis and treatment. We reported a rare clinical case of a 59-year-old male patient who presented to the hospital with a lesion in the left groin area, characterized by raised nodules, gradually increasing in size, accompanied by itching. The disease had been progressing for over 3 years, with no prior history of sexually transmitted infections or urinary tract infections. The patient underwent wide local excision surgery with lymph node dissection. Histopathological findings and postoperative immunohistochemistry confirmed sebaceous gland carcinoma presenting in the left groin area with metastasis to 2 groin lymph nodes. After surgery, the patient underwent adjuvant radiation therapy. At the end of the radiation therapy, no tumor recurrence was detected, and no radiation-related toxicity was noted. The patient was discharged and followed up regularly. The patient remains stable after 6 months of follow-up, with no signs of disease recurrence or treatment complications. In conclusion, inguinal sebaceous gland carcinoma is sporadic, so clinical features and optimal treatment methods are poorly understood. Further research is warranted to clarify this rare condition.