Abstract
Sebaceoma is an infrequently diagnosed benign neoplasm with sebaceous differentiation. This tumor usually presents in areas rich in sebaceous glands, such as the face, scalp, or trunk. The periocular tissues are an exceptionally uncommon site for sebaceoma, making sebaceoma of the eyelid an extremely rare entity. To our knowledge, only five cases of sebaceoma of the eyelid have been reported, with only one of these five originating in a Meibomian gland. Due to its rarity and the wide spectrum of skin lesions, sebaceoma is considered a diagnostically challenging lesion. When the diagnosis is uncertain, a biopsy followed by histopathological analysis should be performed to carefully differentiate sebaceoma from other eyelid tumors. Histopathologically, sebaceoma displays a wide range of patterns, from those seen in sebaceous adenoma to features that can be difficult to distinguish from sebaceous gland carcinoma. We report the case of a 64-year-old Caucasian male presenting with sebaceoma of a Meibomian gland of the left lower eyelid margin. The diagnosis of sebaceoma was made based on a routine histopathological examination.