Abstract
Superficial angiomyxomas of the skin are rare benign cutaneous tumors of soft tissue composed of myxoid matrix and thin-walled blood vessels. They can be sporadic or develop in conjunction with the Carney complex. These tumors have a predilection for the trunk, lower limbs, head, neck, and genitalia. Herein, we report a case of superficial angiomyxoma of the axilla in a 42-year-old man. The pedunculated polypoidal mass showed a maximum diameter of 4.5 cm and intra- and extra-lesional vascularity on Doppler, and the histopathology report was suggestive of myxoid matrix with scattered bland stellate and spindle cells and long thin-walled branching blood vessels and inflammatory infiltrate consisting of mainly neutrophils. Smooth muscle actin (SMA), S100, and desmin were found to be negative on immunohistochemistry, but CD34 was discovered to be positive. It was possible to make the diagnosis of superficial angiomyxoma using these histological and immunohistochemical characteristics. Wide local excision, being the preferred treatment, was performed, and the patient was followed up for six months with no signs of recurrence.