Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri

从红豆杉(Cephalotaxus oliveri)种子中提取的对映体红豆杉生物碱

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Abstract

Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones. The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, MS and calculated ECD spectra. Among them, (+)-acetylcephalofortine C was an enantiomeric Cephalotaxine alkaloids. The performed bioassay revealed that those alkaloids were not cytotoxic against cancer cells and had no neuroprotective properties in the HEI-OC-1 cells model.

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