Abstract
Escherichia coli has developed resistance to most available antibiotics, creating an urgent need for alternative antimicrobial agents. Traditional Chinese Medicine herbs have historically treated infectious diseases and may offer promising alternatives. We investigated the antibacterial activity of five superior class TCM herbs against E. coli using both ethanol extracts and powdered samples. All herbs demonstrated significant zones of inhibition in both forms, suggesting potent antibacterial properties. These findings indicate that TCM herbs warrant further investigation as potential antimicrobial therapies against antibiotic-resistant bacterial infections.