Abstract
The carob tree (Ceratonia siliqua L.) is indigenous to the Mediterranean basin, noted for its adaptability to biotic and abiotic stresses and its long history of use in traditional agroforestry systems. This review critically analyzes the phytochemical composition of carob, its traditional medicinal uses, and its contemporary applications in the cosmetic, pharmaceutical, and agri-food sectors. Particular attention is placed on the valorization of carob pods, seeds, and leaves, which are transformed into high-value products, including locust bean gum and polyphenol-rich extracts. Recent studies indicate that carob is a rich source of bioactive compounds, particularly phenolic acids and flavonoids such as gallic acid, chlorogenic acid, ellagic acid, catechins, quercetin, and luteolin. These compounds have primarily been investigated in vitro and in vivo, where they exhibited antioxidant, antimicrobial, and potential cardioprotective and gastrointestinal-related effects. This chemical diversity underscores their potential as a prime substitute for future nutraceutical and pharmaceutical applications. The review further addresses the ecological and socio-economic relevance of carob cultivation, particularly in countries such as Algeria, where reforestation and agro-industrial valorization remain underexploited despite their significant economic potential. Overall, this work highlights the need for a comprehensive and critical evaluation of carob-derived bioactive compounds and encourages further well-designed studies, especially clinical investigations, to better substantiate their health-related benefits while supporting sustainable use of this multipurpose species.