Abstract
Phytochemical investigation of the methanol extract of Embelia parviflora Wall. Ex A. DC. leaves (Primulaceae family) led to the isolation of sixteen compounds including three sterols (1-3), one triterpene (4), four flavonoids (5-8), four megastigmanes (9-12), three phenolic compounds (13-15), and one furan derivative (16). Their chemical structures were determined based on ESI-MS and NMR spectral data. This is the first chemical study of E. parviflora. Compounds 3, 8-13, and 16 were found in the Embelia genus for the first time. Compounds 9-11, 13, and 16 represent the first isolation from the Primulaceae family. In the α-glucosidase activity assay, MeOH extract, compounds 4 and 5 strongly inhibited enzyme α-glucosidase activity. A molecular docking study revealed that compounds 4 and 5 showed different interactions with enzyme α-glucosidase.