Insertion of a retrotransposon within the 3' end of a mouse gene provides a new functional polyadenylation signal

在小鼠基因的3'端插入逆转录转座子可提供新的功能性多聚腺苷酸化信号。

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Abstract

A site of genomic insertion of the mouse retrotransposon LTR-IS/MuRRS was analysed. The comparison of the genomic and the cDNA clones indicates the insertion of the LTR-IS element into the 3' untranslated region of a mouse gene. The fact that the isolated cDNA clone ends with a poly A tail 20 nucleotides downstream from the LTR-IS AATAAA box and the result of the S1-nuclease mapping provides evidence that the 3' end of the mouse gene transcript was generated under the control of the LTR-IS polyadenylation signal.

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