Abstract
A case of Stevens-Johnson syndrome following treatment with sodium valproate is presented here. A 20-year-old male was put on sodium valproate monotherapy for the migraine, with generalized epilepsy. He developed vesicles and bullae in the oral and nasal mucosa with conjunctivitis, after 10 days of treatment. The lesions resolved after treating with systemic steroids. This case has been presented because Stevens-Johnson syndrome with sodium valproate monotherapy has been very rarely reported.