Abstract
Icodextrin solutions are associated with rashes within a few weeks of initial exposure. However, severe skin reactions are rarely reported. Cessation of icodextrin is necessary for treatment, though systemic steroids were used in a few cases. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe drug reaction characterized by an extensive rash associated with eosinophilia, visceral organ involvement, lymphadenopathy, or atypical lymphocytosis. Recurrence can develop weeks to months after drug cessation, even without re-exposure. To our knowledge, DRESS has not been reported with icodextrin use. Herein, we report a case of relapsing generalized maculopapular skin rash that developed with icodextrin use, highly suggestive of DRESS syndrome.