Abstract
Optic neuritis (ON) is an inflammatory optic nerve injury, which is strongly associated with multiple sclerosis (MS). Axonal damage in the optic nerve manifests as retinal nerve fiber layer (RNFL) deficits, which can be readily quantified with optical coherence tomography (OCT). The RNFL represents the most proximal region of the afferent visual pathway; and, as such, is a unique region of the central nervous system (CNS) because it lacks myelin. Changes in retinal integrity can be correlated with reliable and quantifiable visual outcomes to provide a structural-functional paradigm of CNS injury. Because the eye provides a unique "view" into the effects of CNS inflammation, the ON "system model" may provide greater understanding about disease mechanisms, which underpin disability in MS. This review addresses the applications of OCT in study of ON patients, with specific reference to the published reports to date. The future role of OCT is discussed, both in terms of the potential gains and certain challenges associated with this evolving technology.