Abstract
BACKGROUND: To develop a synthesis within a Bayesian probability framework of previously established evidence, in order to derive an overall conclusion about the hypothesis (H1): 'High-viscosity glass-ionomer cements (HVGIC) are inferior to silver amalgam as (load bearing) restorative materials for permanent posterior teeth'. METHODS: Following Bayesian method, the prior Odds that H1 is true (established from past uncontrolled clinical longitudinal and laboratory trials), the Likelihood Ratio incorporating new evidence (established from recent meta-epidemiological studies and systematic reviews of controlled clinical trials), as well as the posterior hypothesis Odds in view of the new evidence, were calculated. RESULTS: The prior Odds that HVGICs are clinically inferior to amalgam as restorative materials in posterior permanent teeth in relation to the hypothesis that this is not so was 1.12 to 1. The Likelihood Ratio based on new evidence in favor the hypothesis was zero and the subsequent posterior Odds 0 to 1. Therefore, based on the new evidence, the Odds that HVGICs are clinically inferior to amalgam as restorative materials in posterior permanent teeth degreased from 1.12 to zero. CONCLUSION: The current evidence suggests lack of support for the hypothesis that high-viscosity glass-ionomer cements are inferior to silver amalgam as restorative materials for permanent posterior teeth. Should future research to this topic uphold the current findings, a wider range of clinical benefits for both patient and care provider, beyond appropriate restoration longevity for placing HVGIC based restorations may apply.