Abstract
Radiation-induced sarcoma is an exceedingly rare entity associated with high morbidity and mortality even if radiation is received several years prior. Aggressive cancer surveillance following radiotherapy is essential for improving survival rates in patients with radiation-induced sarcoma. Surgical resection with negative margins is the most important factor affecting long-term survival. This case report describes secondary osteosarcoma of the distal third of the femur in a 32-year-old female following previous radiotherapy treatment for Ewing's sarcoma.