Abstract
Sarcomas tend to spread to distant regions, recur locally, and exhibit various histological characteristics. They can also present differently in different areas of the body. Myxofibrosarcoma (MFS) is a typical soft-tissue sarcoma in elderly individuals, distinguished by the presence of both myxoid and fibrous tissue components. This classification might be based on its aggression, with low, middle, and high grades. We address a woman in her 50s who had spindle cell sarcoma measuring 25 x 20 cm(2) on the anterior portion of her right thigh, along with an ulcer and discharge on top of it. The patient was evaluated with a computed tomography lower limb angiogram to look for the vasculature of the swelling. After a wide surgical excision of the mass followed by right anterolateral flap reconstruction, the patient was transferred to medical oncology for further management. The histopathological analysis revealed a grade 2 MFS. The patient has a substantial risk of morbidity and mortality due to the huge size of the sarcoma. This case report discusses the diagnosis and management of MFS, which requires integrated management involving the general surgery, vascular, and plastic surgery teams.