Abstract
Retroperitoneal sarcomas are rare and challenging soft tissue tumors that can have an insidious presentation. These tumors may present asymptomatically or display vague symptoms such as nausea, abdominal pain, and constipation. Rapid detection and treatment of these tumors are necessary as they may metastasize or compress adjacent structures within the body. Imaging and biopsy play a critical role in diagnosing and managing retroperitoneal sarcomas, with treatment decisions largely influenced by the tumor's histological subtype. Due to the high recurrence rate of these tumors, adjuvant therapies and consistent monitoring are essential. This case report discusses the recurrence of a high-grade liposarcoma in a 73-year-old male patient status post retroperitoneal sarcoma resection. Despite initial successful surgical intervention, the patient's non-compliance with follow-up care led to a recurrence, highlighting the importance of long-term monitoring, adherence to post-surgical protocols, and multidisciplinary decision-making.