Abstract
INTRODUCTION: A combined technique of In situ preparation (ISP) and adjuvant radiotherapy in a case of undifferentiated pleomorphic sarcoma (UPS) encasing the radial nerve was attempted successfully, which can be considered for the preservation of neurovascular structure close to soft-tissue sarcomas for a good functional and oncological outcome. CASE PRESENTATION: A 41-year-old female diagnosed with UPS of the left arm underwent, en bloc excision of the lesion along with the preservation of encased radial nerve using ISP followed by adjuvant radiotherapy. The patient has good functional outcome and a local recurrence free and overall survival of 5 years. CONCLUSION: We reported a case of UPS encasing the left radial nerve, where ISP technique and adjuvant radiotherapy were successfully attempted for attaining a good functional and oncological outcome.