Helicobacter pylori primary resistance to metronidazole and clarithromycin in Brazil

巴西幽门螺杆菌对甲硝唑和克拉霉素的原发性耐药

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作者：Prazeres Magalhães,Paula,De Magalhães Queiroz,Dulciene Maria,Campos Barbosa,Daniela Vale,Aguiar Rocha,Gifone,Nogueira Mendes,Edilberto,Santos,Adriana,Valle Corrêa,Paulo Renato,Camargos Rocha,Andreia Maria,Martins Teixeira,Lúcia,Affonso de Oliveira,Celso
期刊：Antimicrobial Agents and Chemotherapy影响因子：4.500
时间：2002起止号：2002 Jun;46(6):2021-3
doi：10.1128/AAC.46.6.2021-2023.2002

Abstract

Helicobacter pylori resistance to metronidazole was detected in 107 (52.97%) of 202 strains. Twenty (9.85%) strains, 18 of them harboring 23S ribosomal DNA mutations, were resistant to clarithromycin. Metronidazole resistance was associated with female gender. Resistance to metronidazole and resistance to clarithromycin were associated. Increasing clarithromycin resistance rates were observed over time.

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