Ribotyping patterns and emergence of metronidazole resistance in paired clinical samples of Helicobacter pylori

幽门螺杆菌配对临床样本的核糖体分型模式及甲硝唑耐药性的出现

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Abstract

Metronidazole-susceptible pretreatment isolates and metronidazole-resistant posttreatment isolates of Helicobacter pylori from 11 patients before and after unsuccessful triple therapy consisting of metronidazole, amoxicillin, and colloidal bismuth subcitrate were studied. Ribotyping (rRNA gene restriction pattern analysis) of the isolates demonstrated that all patients except one had identical digest patterns for pre- and posttreatment isolates.

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