Sequential Gastric MALT Lymphoma and Early Signet Ring Cell Adenocarcinoma in a Patient With Chronic Hepatitis B and Prior Helicobacter pylori Infection

慢性乙型肝炎合并既往幽门螺杆菌感染患者先后发生胃黏膜相关淋巴组织淋巴瘤和早期印戒细胞腺癌

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Abstract

We present the case of a 49-year-old man with cirrhosis secondary to chronic hepatitis B and a history of Helicobacter pylori-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma, who was later found to have an incidental early-stage signet ring cell adenocarcinoma during surveillance. This case highlights the role of chronic inflammation in gastric carcinogenesis and underscores the importance of long-term endoscopic monitoring and the utility of endoscopic submucosal dissection in appropriately selected patients.

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