Abstract
BACKGROUND: The effect of current infection of Helicobacter pylori on gastric cancer has rarely been studied in a large population. We investigated the association of current H. pylori infection and metabolic factors with gastric cancer in a large population. METHODS: Persons who made their first visit to the National Cancer Center for a health examination, including endoscopy and H. pylori testing using gastric tissue between 2003 and 2013, were included. The association of H. pylori with gastric cancer was estimated using odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Among 35,519 people, 113 gastric cancer and 158 gastric dysplasia cases were detected. In the adjusted analysis, gastric cancer was associated with current H. pylori infection (OR, 2.39; 95% CI, 1.53-3.74), age (OR, 1.06; 95% CI 1.04-1.08), first-degree relatives with gastric cancer (OR, 2.08; 95% CI, 1.30-3.32) and hyperglycaemia (OR, 1.66; 95% CI, 1.04-2.65), whereas it was inversely associated with high-density lipoprotein (HDL) (OR, 0.49; 95% CI, 0.22-0.94). In the subanalysis, gastric cancer was associated with first-degree relatives with gastric cancer (OR, 3.23; 95% CI, 1.39-7.50) in the absence of H. pylori, whereas it was associated with hyperglycaemia (OR, 1.98; 95% CI, 1.16-3.39) in the presence of H. pylori. CONCLUSIONS: Gastric cancer was associated with current H. pylori infection, hyperglycaemia, and low HDL levels in a large population.