Abstract
Cancer is the leading cause of death worldwide. The most complicated fact about this disease is early diagnosis. Treatment at advanced stages of the disease is extremely challenging. We need an early cancer detection method. Nanotechnology-based liquid biopsy is an efficient platform for this health crisis. Several advanced modifications to this method ushered in a new era of liquid biopsy. The present article addresses the transforming signature of nanobiotechnology on liquid biopsy techniques (it explores its advantages and limitations).