Abstract
Asthma exacerbations in children may involve systemic coagulation changes reflected by elevated D-dimer levels. Therefore, it is of interest to evaluate 50 children aged 2-15 years to assess the correlation between D-dimer levels and acute exacerbation severity. D-dimer positivity increased significantly with severity-from 9.5% (mild) to 45.5% (moderate) and 71.4% (severe) (p=0.004). Positive D-dimer results were also strongly associated with longer hospital stays (p<0.001). Thus, we show that D-dimer is a valuable biomarker for assessing exacerbation severity and predicting clinical outcomes in pediatric asthma.