Abstract
Prediction of hypertension using indicators such as triglyceride-glucose - waist circumference (TyG-WC) index among Indian adults is gaining momentum in healthcare prognosis and diagnosis for adequate treatment. Therefore, it is of interest to evaluate the TyG-WC index as a non-invasive predictor of hypertension in Indian adults aged 18-45 years. Hence, a cross-sectional study was conducted involving 58 newly diagnosed hypertensive subjects and 72 healthy controls. Independent variables included weight, BMI, WC, TyG and TyG-WC, while hypertension served as the dependent variable, with adjustments for lifestyle and biochemical covariates. Logistic regression and ROC curve analyses were used to assess the association and predictive accuracy of these biomarkers for hypertension. The TyG-WC index demonstrated the strongest predictive power for hypertension (AUC = 0.678, 95% CI: 0.662-0.696, P < 0.001), indicating a significant correlation in young and middle-aged adults.