Abstract
Lung adenocarcinoma (LUAD), the most common kind of lung cancer, is characterized by altered gene expression and DNA methylation. This study used TCGA to evaluate methylation and expression data from LUAD. Differential analysis revealed 7313 methylated genes and 250 upregulated genes. Integration identified "Hypo-Up" genes, which are hypomethylated and elevated, indicating carcinogenic potential. Further protein-protein interaction studies will reveal important seed genes. Data shows severe epigenetic and transcriptome abnormalities in LUAD and suggest new biomarker possibilities.